Portal Diversion

Hepatic encephalopathy and light and electron micrographic changes of the baboon liver after portal diversion.

Six baboons of varying weights and estimated ages had complete portal diversion. All animals became emaciated and lost hair. Five of the 6 developed hepatic encephalopathy so serious that it either killed them or required their sacrifice after an average of 109 days. One exceptional animal which lived for 208 days without encephalopathy had markedly elevated blood ammonia levels. In one brain t...

Portal diversion for the treatment of glycogen storage disease in humans.

Urinary Diversion

I am deeply indebted to the radiologists of the Royal Victoria Hospital, and in particular to Doctor D. C. Porter, for a great deal of help and advice, as well as for the X-ray examinations. I am obliged to the visiting medical staff of the Belfast City Hospital who have kindly allowed me to use their notes and X-rays in some cases. I owe the haematological examinations to Doctor M. G. Nelson a...

Pancreatico-portal dissociation: a canine model to evaluate the hepatic maintenance effects of partial portal flow diversion and pancreatic hormone deprivation.

One hundred years has passed since Nicolai Eck first described the technical feasibility of diverting all portal blood into the inferior vena cava by his now world famous Eck fistula. The physiologic effects of this operation upon hepatic function and regeneration were than unknown. As years have passed, however, investigators have learned that hepatic function and regeneration are impaired, bu...

Preventing Prescription Drug Diversion.

THE FACTS In 2013, more than 43,900 Americans died from drug overdose. Prescription drugs contributed to most of those deaths. Opioid pain relievers like oxycodone, hydrocodone, and methadone were involved in more than 16,000 of those deaths (Centers for Disease Control and Prevention [CDC], 2015). Approximately 46 Americans die every day from drug overdoses (Jones, Mack, & Paulozzi, 2013). Opi...